A Fc-enhanced NTD-binding non-neutralizing antibody delays virus spread and synergizes with a nAb to protect mice from lethal SARS-CoV-2 infection

Author:

Beaudoin-Bussières Guillaume,Chen YaozongORCID,Ullah IrfanORCID,Prévost Jérémie,Tolbert William D.,Symmes KellyORCID,Ding Shilei,Benlarbi MehdiORCID,Gong Shang YuORCID,Tauzin AlexandraORCID,Gasser RomainORCID,Chatterjee Debashree,Vézina Dani,Goyette GuillaumeORCID,Richard Jonathan,Zhou Fei,Stamatatos LeonidasORCID,McGuire Andrew T.,Charest Hughes,Roger Michel,Pozharski Edwin,Kumar PritiORCID,Mothes Walther,Uchil Pradeep D.ORCID,Pazgier MarzenaORCID,Finzi Andrés

Funder

FRQS

Canada Foundation for Innovation

Canada Excellence Research Chairs

Mitacs

NIH

Canadian Institutes of Health Research

Publisher

Elsevier BV

Subject

General Biochemistry, Genetics and Molecular Biology

Reference103 articles.

1. Structural definition of an antibody-dependent cellular cytotoxicity response implicated in reduced risk for HIV-1 infection;Acharya;J. Virol.,2014

2. COVID-19 severity is associated with differential antibody Fc-mediated innate immune functions;Adeniji;mBio,2021

3. Collaboration between the Fab and Fc contribute to maximal protection against SARS-CoV-2 following NVX-CoV2373 subunit vaccine with Matrix-M vaccination;Alter;Res. Sq.,2021

4. The plasmablast response to SARS-CoV-2 mRNA vaccination is dominated by non-neutralizing antibodies that target both the NTD and the RBD;Amanat;medRxiv,2021

5. CD209L/L-SIGN and CD209/DC-SIGN act as receptors for SARS-CoV-2 and are differentially expressed in lung and kidney epithelial and endothelial cells;Amraie;bioRxiv,2020

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