R-etodolac is a more potent Wnt signaling inhibitor than enantiomer, S-etodolac

Author:

Roberts JoAnn S.ORCID,Ma Chao,Robertson Sarah Y.T.ORCID,Kang StephenORCID,Han Christiana S.,Deng Sophie X.,Zheng Jie J.ORCID

Funder

National Eye Institute

Research to Prevent Blindness

Publisher

Elsevier BV

Subject

Biochemistry,Biophysics

Reference32 articles.

1. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury;Etodolac,2012

2. The enantiomers of etodolac, a racemic anti-inflammatory agent, play different roles in efficacy and gastrointestinal safety;Inoue;Biol. Pharm. Bull.,2011

3. The pharmacokinetics of etodolac enantiomers in the rat - lack of pharmacokinetic interaction between enantiomers;Brocks;Drug Metab. Dispos.,1990

4. Sulindac inhibits canonical Wnt signaling by blocking the PDZ domain of the protein dishevelled;Lee;Angew. Chem. Int. Ed.,2009

5. Wnt/beta-Catenin signaling, disease, and emerging therapeutic modalities;Nusse;Cell,2017

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