NVP-BEZ235, a novel dual PI3K–mTOR inhibitor displays anti-glioma activity and reduces chemoresistance to temozolomide in human glioma cells-Reference-Cited by-同舟云学术

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NVP-BEZ235, a novel dual PI3K–mTOR inhibitor displays anti-glioma activity and reduces chemoresistance to temozolomide in human glioma cells

Published:2015-10 Issue:1 Volume:367 Page:58-68
ISSN:0304-3835
Container-title:Cancer Letters
language:en
Short-container-title:Cancer Letters

Author:

Yu Zhiyun,Xie Guifang,Zhou Guangtong,Cheng Ye,Zhang Guangtao,Yao Guangming,Chen Yong,Li Yunqian,Zhao Gang

Funder

National Natural Science Foundation of China

S&T Development Planning Program of Jilin Province

Publisher

Elsevier BV

Subject

Cancer Research,Oncology

Reference34 articles.

1. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma;Stupp;N. Engl. J. Med,2005

2. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial;Stupp;Lancet Oncol,2009

3. Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine;Roos;Oncogene,2007

4. Activation of AMP-activated protein kinase by temozolomide contributes to apoptosis in glioblastoma cells via p53 activation and mTORC1 inhibition;Zhang;J. Biol. Chem,2010

5. Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity;Maira;Mol. Cancer Ther,2008

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