Overexpression of nucleotide metabolic enzyme DUT in hepatocellular carcinoma potentiates a therapeutic opportunity through targeting its dUTPase activity

Author:

Xu Mingjing,Liu Yue,Wan Ho Lee,Wong Alissa M.,Ding Xiaofan,You Wenxing,Lo Wing Sze,Ng Kelvin K-C,Wong Nathalie

Funder

Chinese University of Hong Kong

National Institutes of Health

Charlie Teo Foundation

National Cancer Institute

University Grants Committee Research Grants Council

Publisher

Elsevier BV

Subject

Cancer Research,Oncology

Reference44 articles.

1. Cancer cells tune the signaling pathways to empower de Novo synthesis of nucleotides;Villa;Cancers,2019

2. The role of dUTPase and uracil-DNA repair in cancer chemotherapy;Ladner;Curr. Protein Pept. Sci.,2001

3. dUTP nucleotidohydrolase isoform expression in normal and neoplastic tissues: association with survival and response to 5-fluorouracil in colorectal cancer;Ladner;Cancer Res.,2000

4. Inhibition of dUTPase induces synthetic lethality with thymidylate synthase-targeted therapies in non-small cell lung cancer;Wilson;Mol. Cancer Therapeut.,2012

5. Higher expression of deoxyuridine triphosphatase (dUTPase) may predict the metastasis potential of colorectal cancer;Kawahara;J. Clin. Pathol.,2009

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