Active immunization with a structurally aggregated PD-L1 antigen breaks T and B immune tolerance in non-human primates and exhibits in vivo anti-tumoral effects in immunocompetent mouse tumor models

Author:

Morera-Díaz Y.ORCID,Canaán-Haden C.ORCID,Sánchez-Ramírez J.ORCID,Bequet-Romero M.ORCID,Gonzalez-Moya I.ORCID,Martínez R.,Falcón V.ORCID,Palenzuela D.ORCID,Ayala-Ávila M.ORCID,Gavilondo J.V.

Publisher

Elsevier BV

Subject

Cancer Research,Oncology

Reference21 articles.

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2. CIGB-247: a VEGF-based therapeutic vaccine that reduces experimental and spontaneous lung metastasis of C57Bl/6 and BALB/c mouse tumors;Bequet-Romero;Vaccine,2012

3. PD-L1 Expression in Systemic Immune Cell Populations as a Potential Predictive Biomarker of Responses to PD-L1/pd-1 Blockade Therapy in Lung Cancer;Bocanegra,2019

4. PD-1/PD-L1 pathway: current researches in cancer;Han;Am. Journal.Cancer Res.,2020

5. Optimizing the utilization of aluminum adjuvants in vaccines: you might just get what you want;HogenEsch;npj Vaccines,2018

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