Proton pump inhibitors suppress DNA damage repair and sensitize treatment resistance in breast cancer by targeting fatty acid synthase

Author:

Wang Chao J.ORCID,Li Deren,Danielson Jacob A.ORCID,Zhang Evan H.,Dong Zizheng,Miller Kathy D.,Li Lang,Zhang Jian-TingORCID,Liu Jing-Yuan

Funder

US Department of Defense

National Institutes of Health

Publisher

Elsevier BV

Subject

Cancer Research,Oncology

Reference34 articles.

1. Fatty acid synthase - modern tumor cell biology insights into a classical oncology target;Buckley;Pharmacol. Ther.,2017

2. Biochemistry, molecular biology, and pharmacology of fatty acid synthase, an emerging therapeutic target and diagnosis/prognosis marker;Liu;Int. J. Biochem. Mol. Biol.,2010

3. Fatty acid synthase (FASN) as a therapeutic target in breast cancer;Menendez;Expert Opin. Ther. Targets,2017

4. Overexpression of fatty acid synthase gene activates HER1/HER2 tyrosine kinase receptors in human breast epithelial cells;Vazquez-Martin;Cell Prolif,2008

5. Fatty acid synthase: a metabolic enzyme and candidate oncogene in prostate cancer;Migita;J. Natl. Cancer Inst.,2009

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