The radical scavenger edaravone enhances the anti-tumor effects of CPT-11 in murine colon cancer by increasing apoptosis via inhibition of NF-κB

Author:

Kokura Satoshi,Yoshida Norimasa,Sakamoto Naoyuki,Ishikawa Takeshi,Takagi Tomohisa,Higashihara Hiroshi,Nakabe Nami,Handa Osamu,Naito Yuji,Yoshikawa Toshikazu

Publisher

Elsevier BV

Subject

Cancer Research,Oncology

Reference36 articles.

1. Induction of apoptosis in multi-drug resistant (MDR) human glioblastoma cells by SN-38, a metabolite of the camptothecin derivative CPT-11;Nakatsu;Cancer Chemother. Pharmacol.,1997

2. Topoisomerase poisons activate the transcription factor NF-kappaB in ACH-2 and CEM cells;Piret;Nucleic Acids Res.,1996

3. TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB;Wang;Science,1996

4. Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: implications for systemic nuclear factor-kappaB inhibition;Cusack;Cancer Res.,2001

5. Inducible chemoresistance to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothe cin (CPT-11) in colorectal cancer cells and a xenograft model is overcome by inhibition of nuclear factor-kappaB activation;Cusack;Cancer Res.,2000

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