Cross-linking, DEER-spectroscopy and molecular dynamics confirm the inward facing state of P-glycoprotein in a lipid membrane
Author:
Funder
Worldwide Cancer Research
Publisher
Elsevier BV
Subject
Structural Biology
Reference81 articles.
1. Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1;Alam;Proc. Natl. Acad. Sci. U S A,2018
2. Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding;Aller;Science,2009
3. Transition state analysis of the coupling of drug transport to ATP hydrolysis by P-glycoprotein;Al-Shawi;J. Biol. Chem.,2003
4. Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance;Azzaria;Mol. Cell Biol.,1989
5. Mutations in the nucleotide-binding sites of P-glycoprotein that affect substrate specificity modulate substrate-induced adenosine triphosphatase activity;Beaudet;Biochemistry,1998
Cited by 7 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. The Alternating Access Mechanism in Mammalian Multidrug Resistance Transporters and Their Bacterial Homologs;Membranes;2023-05-30
2. Structural Insights into the Catalytic Cycle of a Bacterial Multidrug ABC Efflux Pump;Journal of Molecular Biology;2022-05
3. Structural Insights into the Catalytic Cycle of a Bacterial Multidrug ABC Efflux Pump;SSRN Electronic Journal;2022
4. Effect of the Force Field on Molecular Dynamics Simulations of the Multidrug Efflux Protein P-Glycoprotein;Journal of Chemical Theory and Computation;2021-09-10
5. Exploiting the metabolic energy demands of drug efflux pumps provides a strategy to overcome multidrug resistance in cancer;Biochimica et Biophysica Acta (BBA) - General Subjects;2021-08
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3