Structural flexibility and functional versatility of cytochrome P450 and rapid evolution

Author:

Negishi Masahiko,Iwasaki Masahiko,Juvonen Risto O.,Sueyoshi Tatsuya,Darden Thomas A.,Pedersen Lee G.

Publisher

Elsevier BV

Subject

Health, Toxicology and Mutagenesis,Genetics,Molecular Biology

Reference37 articles.

1. Lack of the steroid 15α-hydroxylase gene (Cyp 2a-4) in wild mouse strain Mus spretus: rapid evolution of the P450 gene superfamily;Aida;Genomics,1994

2. Sequence requirements for cytochrome P450IIB1 catalytic activity: alteration of the stereospecificity and regiospecificity of steroid hydroxylation by a simultaneous change of two hydrophobic amino acid residues to phenylalanine;Aoyana;J. Biol. Chem.,1989

3. Toward defining the course of evolution minimum change from a specific tree topology;Fitch;Syst. Zool.,1971

4. Evolution of the P450 gene superfamily: animal-plant ‘warfare’, molecular drive and human genetic differences in drug oxidation;Gonzalez;Trends Genet.,1990

5. Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences;Gotoh;J. Biol. Chem.,1992

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