The aprt heterozygote/hemizygote system for screening mutagenic agents allows detection of large deletions
Author:
Publisher
Elsevier BV
Subject
Health, Toxicology and Mutagenesis,Genetics,Molecular Biology
Reference23 articles.
1. High frequency structural gene deletion as the basis for functional hemizygosity of the aprt locus in Chinese hamster ovary cells;Adair,1983
2. Conditional instability of induced variants of CHO, Transient sensitivity to contact with wild-type cells;Bradley;Exp. Cell Res.,1980
3. High frequency nonrandom mutational event at the aprt locus of sib selected CHO variants heterozygous for aprt;Bradley;Somat. Cell Genet.,1982
4. Changing mutant frequencies in cell populations subjected to long-term fractionated doses of radiation may reflect selection for radioresistance;Bradley;Carcinogenesis,1986
5. Molecular characterization of 15 rearrangements among 90 human in vivo somatic mutants shows that deletions predominate;Bradley;Mol. Cell Bio.,1987
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