Reversible and irreversible inhibition of hepatic mitochondrial respiration by acetaminophen and its toxic metabolite, N-acetyl-p-benzoquinoneimine (NAPQI)

Author:

Esterline Russell L.,Dev Ray Sidhartha,Ji Sungchul

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference17 articles.

1. Acute liver necrosis following overdose of paracetamol;Davidson;B Med J,1966

2. Liver damage and impaired glucose tolerance after paracetamol overdosage;Thomson;Br Med J,1966

3. N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen;Dahlin,1984

4. Metabolism and cytotoxicity of acetaminophen in hepatocytes isolated from resistant and susceptible species;Green;Toxicol Appl Pharmacol,1984

5. Paracetamol metabolism and toxicity in isolated hepatocytes from rat and mouse;Moldeus;Biochem Pharmacol,1978

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