Cytotoxicity of 3′-azido-3′-deoxythymidine correlates with 3′-azidothymidine-5′-monophosphate (AZTMP) levels, whereas antihuman immunodeficiency virus (HIV) activity correlates with 3′-azidothymidine-5′-triphosphate (AZTTP) levels in cultured CEM T-lymphoblastoid cells

Author:

Törnevik Yvonne,Ullman Buddy,Balzarini Jan,Wahren Britta,Eriksson Staffan

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference39 articles.

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2. Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotropic virus type III lymphadenopathy-associated virus (HTLV-III/LAV) by 2′,3′-dideoxynucleosides;Mitsuya,1986

3. Anti-retrovirus activity of 3′-fluoro- and 3′-azido substituted pyrimidine 2′3′-dideoxynucleoside analogs;Balzarini;Biochem Pharmacol,1988

4. Administration of 3′-azido-3′-deoxythymidine, an inhibitor of HTLV-III/LAV replication, to patients with AIDS or AIDS-related complex;Yarchoan;Lancet,1986

5. The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial;Fischl;N Eng J Med,1987

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