Intracellular binding is an important determinant of the avid hepatic uptake of the high clearance drug omeprazole

Author:

Sewell Richard B.,Brook Christopher W.,Mihaly George W.,Morgan Denis J.,Small-Wood Richard A.

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference35 articles.

1. Clearance approaches in pharmacology;Wilkinson;Pharmacol Rev,1987

2. First-pass elimination, basic concepts and clinical consequences;Pond;Clin Pharmacokin,1984

3. The disposition of propranolol IV. A dominant role for tissue uptake in the dose-dependent extraction of propranolol by the perfused rat liver;Evans;J Pharmacol Exp Ther,1973

4. Differential effects of hypoxia on the disposition of propranolol and sodium taurocholate by the isolated perfused rat liver;Jones;Hepatology,1982

5. Hepatic uptake of propranolol;Anderson;J Pharmacol Exp Ther,1978

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