In vitro metabolism of 5,8-dideazafolates and 5,8-dideazaisofolates by mammalian folylpoly- γ-glutamate synthetase-Reference-Cited by-同舟云学术

In vitro metabolism of 5,8-dideazafolates and 5,8-dideazaisofolates by mammalian folylpoly- γ-glutamate synthetase

Published:1991-07 Issue:4 Volume:42 Page:833-838
ISSN:0006-2952
Container-title:Biochemical Pharmacology
language:en
Short-container-title:Biochemical Pharmacology

Author:

Coll Richard J.,Cesar Denise,Hynes John B.,Shane Barry

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

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5. A methotrexate-resistant human breast cancer cell line with multiple defects, including diminished formation of methotrexate polyglutamates;Cowan;J Biol Chem,1984

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1. Synthesis and In Vitro Antitumor Activity of Thiophene Analogues of 5-Chloro-5,8-dideazafolic Acid and 2-Methyl-2-desamino-5-chloro-5,8-dideazafolic Acid;Bioorganic & Medicinal Chemistry;2002-06

2. FOLATE CHEMISTRY AND METABOLISM*;Clinical Research and Regulatory Affairs;2001-01

3. The effect of side-chain, para-aminobenzoyl region, and B-ring modifications on dihydrofolate reductase binding, influx via the reduced folate carrier, and cytotoxicity of the potent nonpolyglutamatable antifolate Nα-(4-amino-4-deoxypteroyl)-Nδ-hemiphthaloyl-l-ornithine;Pharmacology & Therapeutics;2000-03

4. 5-Deazafolate Analogues with a Rotationally Restricted Glutamate or Ornithine Side Chain: Synthesis and Binding Interaction with Folylpolyglutamate Synthetase;Journal of Medicinal Chemistry;1999-08-13

5. Synthesis and Potent Antifolate Activity and Cytotoxicity of B-Ring Deaza Analogues of the Nonpolyglutamatable Dihydrofolate Reductase Inhibitor Nα-(4-Amino-4-deoxypteroyl)-Nδ-hemiphthaloyl-l-ornithine (PT523);Journal of Medicinal Chemistry;1998-11-25