5-chloro-substituted derivatives of 2',3'-didehydro-2' ,3'-dideoxyuridine, 3'-fluoro-2' ,3'-dideoxyuridine and 3'-azido-2' ,3'-dideoxyuridine as anti-HIV agents

Author:

Balzarini Jan,Van Aerschot Arthur,Herdewijn Piet,De Clercq Erik

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference10 articles.

1. Anti-HIV-1 activity of 2' ,3'-dideoxynucleoside analogues : structure-activity relationship;De Clercq;Nucleosides & Nucleotides,1988

2. Anti-retrovirus activity of 3'-fluoro- and 3'-azido-substituted pyrimidine 2',3'-dideoxynucleoside analogues;Balzarini;Biochem Pharmacol,1988

3. Vanderhaeghe H, 3'-Substituted 2' ,3'-dideoxynucleoside analogues as potential anti-HIV (HTLV-III/LAV) agents;Herdewijn;J Med Chem,1987

4. 5-Substituted 2'-deoxyuridines: correlation between inhibition of tumor cell growth and inhibition of thymidine kinase and thymidylate synthetase;Balzarini;Biochem Pharmacol,1982

5. Incorporation of 5-substituted pyrimidine nucleoside analogues into DNA of a thymidylate synthetase-deficient murine FM3A carcinoma cell line;Balzarini;Meth and Find Exptl Clin Pharmacol,1985

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