Conversion of irinotecan (CPT-11) to its active metabolite, 7-ethyl-10-hydroxycamptothecin (SN-38), by Human Liver Carboxylesterase

Author:

Rivory Laurent P.,Bowles Mark R.,Robert Jacques,Pond Susan M.

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference15 articles.

1. Synthesis and antitumor activity of 20(S)-camptothecin derivatives: Carbamate-linked, water-soluble derivatives of 7-ethyl-10-hydroxycamptothecin;Sawada;Chem Pharm Bull (Tokyo),1991

2. The current status of camptothecin analogues as antitumor agents;Slichenmyer;J Natl Cancer Inst,1993

3. Molecular, cellular, and clinical aspects of the pharmacology of 20(S)camptothecin and its derivatives;Rivory;Pharmacol Ther,1995

4. Phase I and pharmacological study of the novel topoisomerase I inhibitor 7-ethyl-10-[-4-(1-piperidino)-1-piperidino]-carbonyloxy camptothecin (CPT-11) administered as a ninety-minute infusion every 3 weeks;Rowinsky;Cancer Res,1994

5. Metabolic activation of CPT-11, 7-ethyl-10-[4-(l-piperidino)-1-piperidino]carbonyloxy camptothecin, a novel antitumor agent, by carboxylesterase;Satoh;Biol Pharm Bull,1994

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