Oxidation of acetaminophen to N-acetyl-p-aminobenzoquinone imine by Human CYP3A4

Author:

Thummel Kenneth E.,Lee Caroline A.,Kunze Kent L.,Nelson Sidney D.,Slattery John T.

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference28 articles.

1. Acetaminophen activation by human liver microsomes P45IIE1 and P450IA2;Raucy;Arch Biochem Biophys,1989

2. Comparison of six rabbit liver cytochrome P-450 isozymes in formation of a reactive metabolite of acetaminophen;Morgan;Biochem Biophys Res Commun,1983

3. Cytochrome P-450 isozyme selectivity in the oxidation of acetaminophen;Harvison;Chem Res Toxicol,1988

4. Inhibition and activation of acetaminophen reactive metabolite formation by caffeine: Roles of cytochromes P-450IA1 and IIIA2;Lee;Drug Metab Dispos,1991

5. Thummel KE, Kharasch ED, Podoll T and Kunze K, Human liver microsomal enflurane defluorination catalyzed by cytochrome P-4502E1. Drug Metab Dispos, in press.

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