Evidence that tamoxifen binds to calmodulin in a conformation different to that when binding to estrogen receptors, through structure-activity study on ring-fused analogues

Author:

McCague Raymond,Rowlands Martin G.,Grimshaw Rachel,Jarman Michael

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference22 articles.

1. Tamoxifen is a calmodulin antagonist in the activation of c-AMP phosphodiesterase;Lam;Biochem Biophys Res Commun,1984

2. Calmodulin antagonism and growth inhibiting activity of triphenylethylene antiestrogen in MCF-7 human breast cancer cells;Gulino;Cancer Res,1986

3. Points of action of estrogen antagonist and a calmodulin antagonist within the MCF-7 human breast cancer cell cycle;Musgrove;Cancer Res,1989

4. Effects of tamoxifen, tamoxifen metabolites and nafoxidine on adenosine 3′,5′-monophosphate phosphodiesterase: correlations with growth inhibitory activities, but not estrogen receptor affinities;Fanidi;Endocrinology,1989

5. Properties of a purified estradiol-dependent calf uterus tyrosine kinase;Castoria;Biochemistry,1993

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