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The mechanism of activation of monomeric B-Raf V600E

  • Published:2021 Issue: Volume:19 Page:3349-3363
  • ISSN:2001-0370
  • Container-title:Computational and Structural Biotechnology Journal
  • language:en
  • Short-container-title:Computational and Structural Biotechnology Journal

Author:

Maloney Ryan C.,Zhang Mingzhen,Jang Hyunbum,Nussinov Ruth

Funder

U.S. Department of Health and Human Services

National Cancer Institute

National Institutes of Health

Government of South Australia

Publisher

Elsevier BV

Subject

Computer Science Applications,Genetics,Biochemistry,Structural Biology,Biophysics,Biotechnology

Reference90 articles.

1. BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas;Pfister;J Clin Invest,2008

2. Regulation of RAF protein kinases in ERK signalling;Lavoie;Nat Rev Mol Cell Biol England,2015

3. Allosteric activation of RAF in the MAPK signaling pathway;Tsai;Curr Opin Struct Biol,2018

4. Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism;Kornev;PNAS,2006

5. Germline gain-of-function mutations in RAF1 cause;Razzaque;Noonan Syndrome,2007

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