Inhibitors of sterol synthesis. Chemical syntheses, properties and effects of 4,4-dimethyl-15-oxygenated sterols on sterol synthesis and on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured mammalian cells-Reference-Cited by-同舟云学术

Inhibitors of sterol synthesis. Chemical syntheses, properties and effects of 4,4-dimethyl-15-oxygenated sterols on sterol synthesis and on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured mammalian cells

Published:1988-07 Issue:3 Volume:47 Page:187-207
ISSN:0009-3084
Container-title:Chemistry and Physics of Lipids
language:en
Short-container-title:Chemistry and Physics of Lipids

Author:

Schroepfer G.J.,Parish Edward J.,Tsuda Mitsuhiro,Kandutsch Andrew A.

Publisher

Elsevier BV

Subject

Cell Biology,Organic Chemistry,Molecular Biology,Biochemistry

Reference49 articles.

1. Inhibition of sterol biosynthesis in L cells and mouse liver cells by 15-oxygenated sterols.

2. 14.alpha.-Ethyl-5.alpha.-cholest-7-ene-3.beta.,15.alpha.-diol, an extraordinarily potent inhibitor of sterol biosynthesis in animal cells

3. Inhibition of sterol synthesis in L cells by 14α-ethyl-5α-cholest-7-en-15α-ol-3-one at nanomolar concentrations

4. Inhibition of sterol synthesis in animal cells by 15-oxygenated sterols with the unnatural cis-c-d ring junction—5α, 14β-Cholest-7-en-15α-ol-3-one and 5α, 14β-Cholest-7-en-15β-ol-3-one

5. Inhibition of sterol biosynthesis in animal cells by 14 alpha-alkyl-substituted 15-oxygenated sterols.

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