No influence of enzyme inhibitors on the hydroxylation of methotrexate in rats

Author:

Yu D.,Brasch H.,Iven H.

Publisher

Elsevier BV

Subject

Cancer Research,Oncology

Reference14 articles.

1. Pharmacokinetics of methotrexate and 7-hydroxymethotrexate following infusions of high-dose methotrexate;Breithaupt;Cancer Treat. Rep.,1982

2. Tissue metabolism and distribution of methotrexate in rabbits;Chen;Drug Metab. Dispos.,1982

3. Inhibition by cyanamide of 4-hydroxyphosphamide/aldophosphamide oxidation to carboxyphosphamide;Domeyer;Biochem. Pharmacol.,1981

4. Allopurinol and other inhibitors of urate synthesis;Elion,1978

5. Pharmacokinetics of methotrexate (MTX) and 7-hydroxy-methotrexate (7-OH-MTX) in rats and evidence for the metabolism of MTX to 7-OH-MTX;Fahrig;Cancer Chemother. Pharmacol.,1989

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. In vivo-In vitro Relationship of Methotrexate 7-Hydroxylation by Aldehyde Oxidase in Four Different Strain Rats;Drug Metabolism and Pharmacokinetics;2006

2. Strain differences of the ability to hydroxylate methotrexate in rats;Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology;1999-03

3. Inhibition of 7-hydroxymethotrexate formation by amsacrine;Cancer Chemotherapy and Pharmacology;1991

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