An efficient synthesis of a highly functionalized 4-arylpiperidine

Author:

Boice Geneviève N.,Savarin Cécile G.,Murry Jerry A.,Conrad Karen,Matty Louis,Corley Edward G.,Smitrovich Jacqueline H.,Hughes Dave

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference32 articles.

1. Synthesis of N-Substituted 4-(4-Hydroxyphenyl)piperidines, 4-(4-Hydroxybenzyl)piperidines, and (±)-3-(4-Hydroxyphenyl)pyrrolidines:  Selective Antagonists at the 1a/2B NMDA Receptor Subtype

2. (b) Binggeli, A.; Breu, V.; Bur, D.; Fischli, W.; Gueller, R.; Hirth, G.; Maerki, H-P.; Mueller, M.; Oefner, C.; Stadler, H.; Vieira, E.; Wilhelm, M.; Wostl, W. International Patent WO 97/09311, March 13, 1997.

3. From Peptides to Non-Peptide Peptidomimetics:  Design and Synthesis of New Piperidine Inhibitors of Aspartic Peptidases

4. In Vitro and in Vivo Evaluation of Dihydropyrimidinone C-5 Amides as Potent and Selective α1A Receptor Antagonists for the Treatment of Benign Prostatic Hyperplasia

5. (e) Nieman, J. A.; Fang, L.; Jagodzinska, B. International Patent WO 02/076440, October 3, 2002.

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