Design, synthesis, and biological evaluation of indole-2-carboxamides as SARS CoV-2 main protease inhibitors

Author:

Gomaa Hesham A.M.,Shaker Mohamed E.,Alzarea Sami I.,Alsahli Tariq G.,Hendawy Omnia,Mohammed Yasser Khamis,Khaled Younes M.,El-Zahraa S. Abdel Rahman Fatema,Mohamed Fatma A.M.,Abdel Raoof Gehan Fawzy,Mahmoud Mohamed A.,Gouda Ahmed M.,Bakr Adel G.,Youssif Bahaa G.M.ORCID

Funder

Deanship of Scientific Research, University of Jordan

Jouf University

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference45 articles.

1. The trinity of COVID-19: immunity, inflammation and intervention;Tay;Nat. Rev. Immunol.,2020

2. Topological analysis of SARS CoV-2 main protease, Chaos;Estrada;An Interdisciplinary Journal of Nonlinear Science,2020

3. Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors;Zhang;Science,2020

4. Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease;Dai;Science,2020

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