Synthesis and characterization of an isopropylBippyPhos precatalyst

Author:

Coffey Steven B.,Bernhardson David J.ORCID,Wright Stephen W.ORCID

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference44 articles.

1. For recent reviews of palladium catalyzed chemistries, see:

2. Cross-coupling and related reactions: connecting past success to the development of new reactions for the future;Campeau;Organometallics,2019

3. Application of palladium-catalyzed cross-coupling reactions in organic synthesis;Sain;Curr. Org. Synth.,2019

4. Enabling palladium/phosphine-catalyzed cross-coupling reactions for practical applications Org;Guram;Process Res. Dev.,2016

5. A review of our internal electronic laboratory notebooks showed that Pfizer medicinal chemists engaged in discovery research conducted the following approximate numbers of palladium catalyzed chemistries in 2016: 3000 Suzuki – Miyaura couplings; 1150 borylation reactions; 1000 Buchwald – Hartwig aminations and etherifications, 320 Stille couplings, 190 carbonylations, 170 Sonagashira couplings, 130 cyanations, and 80 Heck reactions.

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