TGF-β: the missing link in CD4+CD25+ regulatory T cell-mediated immunosuppression

Author:

Chen WanJun,Wahl Sharon M

Publisher

Elsevier BV

Subject

General Biochemistry, Genetics and Molecular Biology,Immunology,Immunology and Allergy,Endocrinology, Diabetes and Metabolism

Reference35 articles.

1. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25): breakdown of a single mechanism of self-tolerance causes various autoimmune diseases;Sakaguchi;J. Immunol.,1995

2. Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation;Read;J. Exp. Med.,2000

3. Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta;Nakamura;J. Exp. Med.,2001

4. A functional link between CTLA-4 and cell surface-associated TGF-β in CD4+CD25+ suppressor T cell-mediated immunosuppression;Chen;FASEB J.,2002

5. Production of transforming growth factor β by human T lymphocytes and its potential role in the regulation of T cell growth;Kehrl;J. Exp. Med.,1986

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