Involvement of CYP2D6, CYP3A4, and other cytochrome P-450 isozymes in N-dealkylation reactions

Author:

Coutts Ronald T.,Su Ping,Baker Glen B.

Publisher

Elsevier BV

Subject

Pharmacology,Toxicology

Reference79 articles.

1. Relationship of N-demethylation of amiflamine and its metabolite to debrisoquine hydroxylation polymorphism;Alván;Clin Pharmacol Ther,1984

2. High plasma concentration of desmethylclomipramine after chronic administration of clomipramine to a poor metabolizer;Balant-Gorgia;Eur J Clin Pharmacol,1987

3. Persistent impairment of clomipramine demethylation in recently detoxified alcoholic patients;Balant-Gorgia;Ther Drug Monit,1992

4. Characterization of the cytochrome P-450 gene family responsible for the N-dealkylation of the ergot alkaloid CQA206-291 in humans;Ball;Drug Metab Dispos,1992

5. Lidocaine metabolism in human liver microsomes by cytochrome P450IIIA4;Bargetzi;Clin Pharmacol Ther,1989

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