Palmitoylation on the carboxyl terminus tail is required for the selective regulation of dopamine D 2 versus D 3 receptors

Author:

Zhang Xiaowei,Le Hang Thi,Zhang Xiaohan,Zheng Mei,Choi Bo-Gil,Kim Kyeong-Man

Funder

KRF

Publisher

Elsevier BV

Subject

Cell Biology,Biochemistry,Biophysics

Reference34 articles.

1. Role of palmitoylation/depalmitoylation reactions in G-protein-coupled receptor function;Qanbar;Pharmacol. Ther.,2003

2. Two adjacent cysteine residues in the C-terminal cytoplasmic fragment of bovine rhodopsin are palmitylated;Ovchinnikov Yu;FEBS Lett.,1988

3. Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor;O'Dowd;J. Biol. Chem.,1989

4. Mutations of the alpha 2A-adrenergic receptor that eliminate detectable palmitoylation do not perturb receptor-G-protein coupling;Kennedy;J. Biol. Chem.,1993

5. The palmitoylated cysteine of the cytoplasmic tail of alpha 2A-adrenergic receptors confers subtype-specific agonist-promoted downregulation;Eason;Proc. Natl. Acad. Sci. U. S. A.,1994

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