Clinical phase II study and pharmacological evaluation of rubitecan in non-pretreated patients with metastatic colorectal cancer—significant effect of food intake on the bioavailability of the oral camptothecin analogue

Author:

Schöffski P,Herr A,Vermorken J.B,Van den Brande J,Beijnen J.H,Rosing H,Volk J,Ganser A,Adank S,Botma H.J,Wanders J

Publisher

Elsevier BV

Subject

Cancer Research,Oncology

Reference21 articles.

1. Plant antitumor agents. I. The isolation and structure of Camptothecin, a novel alkaloidal leukemia and tumor inhibitor form Camptotheca acuminata;Wall;J. Am. Chem. Soc.,1966

2. Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin;Hsiang;Cancer Res.,1988

3. 9-nitro-camptothecin delays growth of U-937 leukemia tumors in nude mice and is cytotoxic or cytostatic for human myelomonocytic leukemia lines in vitro;Pantazis;Eur. J. Haematol.,1993

4. In vitro antitumor activity of 9-nitro-camptothecin as a single agent and in combination with other antitumor drugs;Bernacki;Ann. N. Y. Acad. Sci.,2000

5. Pharmacokinetics of the in vivo and in vitro conversion of 9-nitro-20(S)-camptothecin to 9-amino-20(S)-camptothecin in humans, dogs and mice;Hinz;Cancer Res.,1994

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