Farnesyl transferase inhibitors as anticancer agents

Author:

Haluska P,Dy G.K,Adjei A.A

Publisher

Elsevier BV

Subject

Cancer Research,Oncology

Reference129 articles.

1. Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity;Kato;Proc. Natl. Acad. Sci. USA,1992

2. A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and-independent growth of human tumor cell lines;Sepp-Lorenzino;Cancer Res.,1995

3. Inhibition of human tumor xenograft growth by treatment with the farnesyl transferase inhibitor B956;Nagasu;Cancer Res.,1995

4. Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts;Sun;Oncogene,1998

5. Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines;Lerner;Oncogene,1997

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