DNA interstrand cross-linking and TP53 status as determinants of tumour cell sensitivity in vitro to the antibody-directed enzyme prodrug therapy ZD2767

Author:

Monks Noel R.,Blakey David C.,East Simon J.,Dowell Robert I.,Calvete Joanne A.,Curtin Nicola J.,Arris Christine E.,Newell David R.

Publisher

Elsevier BV

Subject

Cancer Research,Oncology

Reference30 articles.

1. Trends in drug targeting for cancer;Singh;Drug Delivery,1996

2. Novel therapeutic strategies to selectively kill cancer cells;Panchal;Biochem. Pharmacol.,1988

3. Antibody directed enzymes revive anti-cancer prodrugs concept;Bagshawe;Br. J. Cancer,1987

4. Optimization of alkylating agent prodrugs derived from phenol and aniline mustards: a new clinical candidate prodrug (ZD2767) for antibody-directed enzyme prodrug therapy (ADEPT);Springer;J. Med. Chem.,1995

5. ZD2767, an improved system for antibody-directed enzyme prodrug therapy that results in tumour regressions in colorectal tumour xenografts;Blakey;Cancer Res.,1996

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