Application of particle swarm optimization to understand the mechanism of action of allosteric inhibitors of the enzyme HSD17β13

Author:

Ford Amy,Breitgoff Frauke,Pasquini Miriam,MacKenzie Amanda,McElroy Stuart,Baker Steve,Abrusci Patrizia,Varzandeh Simon,Bird Louise,Gavard Angeline,Damerell David,Redhead Martin

Publisher

Elsevier BV

Subject

General Decision Sciences

Reference22 articles.

1. Screening for Allosteric Kinase Inhibitors in High Throughput - 2010 - Wiley Analytical Science https://analyticalscience.wiley.com/do/10.1002/gitlab.708.

2. High-throughput screening to identify inhibitors which stabilize inactive kinase conformations in p38α;Simard;J. Am. Chem. Soc.,2009

3. A combinatorial biophysical approach; FTSA and SPR for identifying small molecule ligands and PAINs;Redhead;Anal. Biochem.,2015

4. Thermal shift as an entropy-driven effect;Redhead;Biochemistry,2017

5. Measurement of nanomolar dissociation constants by titration calorimetry and thermal shift assay – radicicol binding to Hsp90 and ethoxzolamide binding to CAII;Zubrienė;Int. J. Mol. Sci.,2009

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