Synthesis of 11β-(4-dimethylaminophenyl)-17β-hydroxy-17α- (3-methyl-1-butynyl)-4, 9-estradien-3-one and 11β-(4-acetophenyl)- 17β-hydroxy-17α-(3-methyl-1-butynyl)-4, 9-estradien-3-one: two new analogs of mifepristone (RU-486)☆,☆☆21☆☆ This work originated at the National Chemical Laboratory, Pune 411 008, India.,☆☆☆22☆☆☆ Dedicated to Prof. D. Nasipuri on his 75th birthday.-Reference-Cited by-同舟云学术

Synthesis of 11β-(4-dimethylaminophenyl)-17β-hydroxy-17α- (3-methyl-1-butynyl)-4, 9-estradien-3-one and 11β-(4-acetophenyl)- 17β-hydroxy-17α-(3-methyl-1-butynyl)-4, 9-estradien-3-one: two new analogs of mifepristone (RU-486)☆,☆☆21☆☆ This work originated at the National Chemical Laboratory, Pune 411 008, India.,☆☆☆22☆☆☆ Dedicated to Prof. D. Nasipuri on his 75th birthday.

Published:2000-03 Issue:3 Volume:65 Page:157-162
ISSN:0039-128X
Container-title:Steroids
language:en
Short-container-title:Steroids

Author:

Hazra Braja G,Basu Sourav,Pore Vandana S,Joshi Padmakar L,Pal Debnath,Chakrabarti Pinak

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Pharmacology,Endocrinology,Molecular Biology,Biochemistry

Reference17 articles.

1. RU-486;Ulmann;Scientific American,1990

2. Baulieu E-E. Contragestion and other clinical applications of RU-486, an antiprogesterone at the receptor. Science 1989;245:1351–7.

3. Teutsch Jean G, Costerousse G, Philibert D, Deraedt R, Roussel–Uclaf. Steroid derivatives substituted at 11β-position. FR Patent 2, 497, 807 Chem Abstr 1983;98:54293q.

4. Philibert D, Teutsch Jean G, Costerousse G, Deraedt R, Roussel–Uclaf. Derivatives of 3-oxo-4,9-unsaturated 19-norsteroids and their pharmaceutical compositions. Ger Offen DE 3, 307, 143. Chem Abstr 1984;100:68601k.

5. Synthetic variations of the progesterone antagonist RU 38 486;Neef;Tetrahedron Lett,1984

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