Development of a quantitative cell-based ELISA, for a humanized anti-IL-2/IL-15 receptor β antibody (HuMikβ1), and correlation with functional activity using an antigen-transfected murine cell line

Author:

Yang Xiao Yi,Chen Eying,Jiang Hengguang,Hartmann Wanda K.,Mitra Gautam,Hecht Toby,Soman Gopalan

Publisher

Elsevier BV

Subject

Immunology,Immunology and Allergy

Reference25 articles.

1. An assay for transforming growth factor-β using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct;Abe;Anal. Biochem.,1994

2. Involvement of IL-15 in the pathogenesis of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis: implications for therapy with a monoclonal antibody directed to the IL-2/15R β receptor;Azimi;J. Immunol.,1999

3. The interleukin (IL) 2 receptor β chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells;Bamford;Proc. Natl. Acad. Sci. U. S. A.,1994

4. Humanized antibodies against the α-chain of the IL-2 receptor and against the β-chain shared by the IL-2 and IL-15 receptors in a monkey uveitis model of autoimmune diseases;Guex-Crosier;J. Immunol.,1997

5. Humanized Mikβ1, a humanized antibody to the IL-2 receptor β-chain that acts synergistically with humanized anti-TAC;Hakimi;J. Immunol.,1993

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