A metabonomics-based renoprotective mechanism analysis of empagliflozin in obese mice

Author:

Chen XingORCID,Chen Shuchun,Ren Qingjuan,Niu Shu,Yue Lin,Pan Xiaoyu,Li Zelin,Zhu Ruiyi,Jia Zhuoya,Chen Xiaoyi,Zhen Ruoxi,Ban Jiangli

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Reference36 articles.

1. Liraglutide improves obesity-induced renal injury by alleviating uncoupling of the glomerular VEGF-NO axis in obese mice;Li;Clin. Exp. Pharmacol. Physiol.,2020

2. Aldosterone is involved in the pathogenesis of obesity-related glomerulopathy through activation of Wnt/β-catenin signaling in podocytes;Zhu;Mol. Med. Rep.,2018

3. The sodium-glucose cotransporter 2 inhibitor dapagliflozin prevents renal and liver disease in western diet induced obesity mice;Wang;Int. J. Mol. Sci.,2018

4. Therapy of empagliflozin plus metformin on T2DM mice shows no higher amelioration for glucose and lipid metabolism than empagliflozin monotherapy;Wang;Life Sci.,2019

5. The SGLT-2 inhibitor dapagliflozin has a therapeutic effect on atherosclerosis in diabetic ApoE(-/-) mice;Leng;Mediat. Inflamm.,2016

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