Normal aging induces PD-1-enriched exhausted microglia and A1-like reactive astrocytes in the hypothalamus

Author:

Suda Yukari,Nakashima ToshihisaORCID,Matsumoto Hiroaki,Sato Daisuke,Nagano Satoshi,Mikata Haruka,Yoshida Sara,Tanaka Kenichi,Hamada Yusuke,Kuzumaki Naoko,Narita Minoru

Funder

Hoshi University

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Reference19 articles.

1. Alzheimer’s disease is associated with altered expression of genes involved in immune response and mitochondrial processes in astrocytes;Sekar;Neurobiol. Aging,2015

2. Proteomic evidence of biological aging in a child with a compound heterozygous ZMPSTE24 mutation;Lucas-Herald;Proteonomics Clin. Appl.,2019

3. Werner syndrome: clinical features, pathogenesis and potential therapeutic interventions;Oshima;Ageing Res. Rev.,2017

4. Brain-immune interactions and disease susceptibility;Marques-Deak;Mol. Psychiatr.,2005

5. Systemic regulation of mammalian ageing and longevity by brain sirtuins;Satoh;Nat. Commun.,2014

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