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Genistein protects against acetaminophen-induced liver toxicity through augmentation of SIRT1 with induction of Nrf2 signalling

  • Published:2020-06 Issue:1 Volume:527 Page:90-97
  • ISSN:0006-291X
  • Container-title:Biochemical and Biophysical Research Communications
  • language:en
  • Short-container-title:Biochemical and Biophysical Research Communications

Author:

Wang Linpei,Li Anquan,Liu Yinhao,Zhan Shiyang,Zhong Lei,Du Youqin,Xu Dongyao,Wang Wei,Huang Weifeng

Funder

Fujian Medical University

science and technology projects in Quanzhou

Quanzhou Science and Technology Innovation Project

Fujian Provincial Health and Planning Commission Youth Project

Ministry of Education, Yantai University

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Reference35 articles.

1. Acetaminophen hepatotoxicity: a mitochondrial perspective;Ramachandran;Adv. Pharmacol.,2019

2. Acetaminophen: dose-dependent drug hepatotoxicity and acute liver failure in patients;Jaeschke;Dig. Dis.,2015

3. Acetaminophen hepatotoxicity;Ramachandran;Semin. Liver Dis.,2019

4. Sir2 links chromatin silencing, metabolism, and aging;Guarente;Genes Dev.,2000

5. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase;Vaziri;Cell,2001
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