Crystalline silica particles induce DNA damage in respiratory epithelium by ATX secretion and Rac1 activation
Author:
Funder
Karolinska Institutet
Publisher
Elsevier BV
Subject
Cell Biology,Molecular Biology,Biochemistry,Biophysics
Reference22 articles.
1. ATM-activated autotaxin (ATX) propagates inflammation and DNA damage in lung epithelial cells: a new mode of action for silica-induced DNA damage?;Zheng;Carcinogenesis,2017
2. Crystalline silica particles cause rapid NLRP3-dependent mitochondrial depolarization and DNA damage in airway epithelial cells;Wu;Part. Fibre Toxicol.,2020
3. Signalling by lysophosphatidate and its health implications;Hemmings;Essays Biochem.,2020
4. Toluene diisocyanate: induction of the autotaxin-lysophosphatidic acid axis and its association with airways symptoms;Brostrom;Toxicol. Appl. Pharmacol.,2015
5. Micromolar changes in lysophosphatidylcholine concentration cause minor effects on mitochondrial permeability but major alterations in function;Hollie;Biochim. Biophys. Acta,2014
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1. High-fat Western diet alters crystalline silica-induced airway epithelium ion transport but not airway smooth muscle reactivity;BMC Research Notes;2024-01-03
2. Crystalline silica-exposed human lung epithelial cells presented enhanced anchorage-independent growth with upregulated expression of BRD4 and EZH2 in autocrine and paracrine manners;PLOS ONE;2023-05-05
3. ATX-LPA-Dependent Nuclear Translocation of Endonuclease G in Respiratory Epithelial Cells: A New Mode Action for DNA Damage Induced by Crystalline Silica Particles;Cancers;2023-01-30
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