The p105 NF-ĸB precursor is a pseudo substrate of the ubiquitin ligase FBXO7, and its binding to the ligase stabilizes it and results in stimulated cell proliferation-Reference-Cited by-同舟云学术

The p105 NF-ĸB precursor is a pseudo substrate of the ubiquitin ligase FBXO7, and its binding to the ligase stabilizes it and results in stimulated cell proliferation

Published:2021-06 Issue: Volume:558 Page:224-230
ISSN:0006-291X
Container-title:Biochemical and Biophysical Research Communications
language:en
Short-container-title:Biochemical and Biophysical Research Communications

Author:

Udasin Ronald G.,Gottfried Yossi,Fabre Bertrand,Bercovich Beatrice,Ziv Tamar,Ciechanover Aaron

Funder

German-Israeli Foundation for Scientific Research and Development

H2020 Marie Skłodowska-Curie Actions

Dr. Miriam and Sheldon G. Adelson Medical Research Foundation

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Reference24 articles.

1. KPC1-mediated ubiquitination and proteasomal processing of NF-kappaB1 p105 to p50 restricts tumor growth;Kravtsova-Ivantsiv;Cell,2015

2. The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction;Glickman;Physiol. Rev.,2002

3. NF-kappaB and the link between inflammation and cancer;DiDonato;Immunol. Rev.,2012

4. The diverse and complex roles of NF-kappaB subunits in cancer;Perkins;Nat. Rev. Canc.,2012

5. Structural motifs involved in ubiquitin-mediated processing of the NF-kappaB precursor p105: roles of the glycine-rich region and a downstream ubiquitination domain;Orian;Mol. Cell Biol.,1999

Cited by 7 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Gramine improves sepsis-induced myocardial dysfunction by binding to NF-κB p105 and inhibiting its ubiquitination;Phytomedicine;2024-03

2. Koumine inhibits RANKL‐induced ubiquitination and NF‐κB activation to prevent ovariectomy and aging‐induced bone loss;Journal of Cellular Biochemistry;2023-11-30

3. FBXO7 Confers Mesenchymal Properties and Chemoresistance in Glioblastoma by Controlling Rbfox2‐Mediated Alternative Splicing;Advanced Science;2023-10-11

4. Somatic gain-of-function mutations in BUD13 promote oncogenesis by disrupting Fbw7 function;Journal of Experimental Medicine;2023-06-29

5. The Tumor Suppressor Functions of Ubiquitin Ligase KPC1: From Cell-Cycle Control to NF-κB Regulator;Cancer Research;2023-03-07