The M358R variant of α 1 -proteinase inhibitor inhibits coagulation factor VIIa

Author:

Sheffield William P.ORCID,Bhakta Varsha

Funder

Heart and Stroke Foundation of Ontario

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Reference30 articles.

1. Serpin structure, function and dysfunction;Huntington;J. Thromb. Haemost.,2011

2. Mutation of antitrypsin to antithrombin. alpha 1-antitrypsin Pittsburgh (358 Met leads to Arg), a fatal bleeding disorder;Owen;N. Engl. J. Med.,1983

3. Evolution of serpin specificity: cooperative interactions in the reactive-site loop sequence of antithrombin specifically restrict the inhibition of activated protein C;Hopkins;J. Mol. Evol.,2000

4. Alpha-1-antitrypsin-Pittsburgh. A potent inhibitor of human plasma factor XIa, kallikrein, and factor XIIf;Scott;J. Clin. Investig.,1986

5. Inhibition of activated protein C by recombinant alpha 1-antitrypsin variants with substitution of arginine or leucine for methionine358;Heeb;J. Biol. Chem.,1990

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