Orotate phosphoribosyltransferase expression level in tumors is a potential determinant of the efficacy of 5-fluorouracil

Author:

Sakamoto Etsuko,Nagase Hideki,Kobunai Takashi,Oie Shinji,Oka Toshinori,Fukushima Masakazu,Oka Tatsuzo

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Reference24 articles.

1. 5-Fluorouracil: mechanisms of action and clinical strategies;Longley;Nat. Rev. Cancer,2003

2. Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors;Johnston;Cancer Res.,1995

3. Combination of dihydropyrimidine dehydrogenase and thymidylate synthase gene expressions in primary tumors as predictive parameters for the efficacy of fluoropyrimidine-based chemotherapy for metastatic colorectal cancer;Ichikawa;Clin. Cancer Res.,2003

4. A comparison of 5-fluorouracil metabolism in human colorectal cancer and colon mucosa;Peters;Cancer,1991

5. Mammalian pyrimidine biosynthesis: fresh insights into an ancient pathway;Evans;J. Biol. Chem.,2004

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