PKC412 (CGP41251) modulates the proliferation and lipopolysaccharide-induced inflammatory responses of RAW 264.7 macrophages

Author:

Miyatake Katsutoshi,Inoue Hiroshi,Hashimoto Kahoko,Takaku Hiroshi,Takata Yoichiro,Nakano Shunji,Yasui Natsuo,Itakura Mitsuo

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Reference23 articles.

1. PKC412-a protein kinase inhibitor with a broad therapeutic potential;Fabbro;Anticancer Drug Des.,2000

2. Antitumor activity of the new selective protein kinase C inhibitor 4′-N-benzoyl staurosporine on murine and human tumor models;Ikegami;Arzneimittelforschung,1995

3. Phase I and pharmacokinetic study of PKC412, an inhibitor of protein kinase C;Propper;J. Clin. Oncol.,2001

4. Phase I study of PKC412 (N-benzoyl-staurosporine), a novel oral protein kinase C inhibitor, combined with gemcitabine and cisplatin in patients with non-small-cell lung cancer;Monnerat;Ann. Oncol.,2004

5. Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412;Stone;Blood,2005

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