Human ex-vivo action potential model for pro-arrhythmia risk assessment

Author:

Page Guy,Ratchada Phachareeya,Miron Yannick,Steiner Guido,Ghetti Andre,Miller Paul E.,Reynolds Jack A.,Wang Ken,Greiter-Wilke Andrea,Polonchuk Liudmila,Traebert Martin,Gintant Gary A.,Abi-Gerges Najah

Funder

NIH Small Business Innovation Research (SBIR)

Publisher

Elsevier BV

Subject

Pharmacology,Toxicology

Reference53 articles.

1. Transmural electrophysiological heterogeneities underlying arrhythmogenesis in heart failure;Akar;Circulation Research,2003

2. ICH S7B note for guidance on the nonclinical evaluation of the potential for delayed ventricular repolarization (QT interval prolongation) by human pharmaceuticals. London, 25 May. Reference CHMP/ICH/423/02;Anon.,2005

3. ICH E14 note for guidance on the clinical evaluation of QT/QTc interval prolongation and proarrhythmic potential for nonantiarrhythmic drugs. London, 25 May. Reference CHMP/ICH/2/04;Anon.,2005

4. Transmural APD gradient synchronizes repolarization in the human left ventricular wall;Boukens;Cardiovascular Research,2015

5. Organotypic slice culture from human adult ventricular myocardium;Brandenburger;Cardiovascular Research,2012

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