Comparison of 5 methods of QT interval measurements on electrocardiograms from a thorough QT/QTc study: effect on assay sensitivity and categorical outliers

Author:

Salvi Vaibhav,Karnad Dilip R.,Panicker Gopi Krishna,Natekar Mili,Hingorani Pooja,Kerkar Vaibhav,Ramasamy Arumugam,de Vries Michiel,Zumbrunnen Troy,Kothari Snehal,Narula Dhiraj

Publisher

Elsevier BV

Subject

Cardiology and Cardiovascular Medicine

Reference30 articles.

1. International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use. The clinical evaluation of QT/QTc interval prolongation and proarrhythmic potential for non-antiarrhythmic drugs: E14. Geneva, Switzerland: International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use; 2005. Available at http://www.ich.org/LOB/media/MEDIA1476.pdf. Accessed 10 Oct 2008.

2. QT interval measurement: what can we really expect?;Xue;Comput Cardiol,2006

3. Assessment of ventricular repolarization from body-surface ECGs in humans;Couderc,2005

4. The measurement of the QT interval of the electrocardiogram;Lepeschkin;Circulation,1952

5. Z score for benchmarking reader competence in a central ECG laboratory;Panicker;Ann Noninvasive Electrocardiol,2009

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