Physiologically based pharmacodynamic modeling of an interaction threshold between trichloroethylene and 1,1-dichloroethylene in fischer 344 rats

Author:

El-Masri Hisham A.,Constan Alexander A.,Ramsdell Howard S.,Yang Raymond S.H.

Publisher

Elsevier BV

Subject

Pharmacology,Toxicology

Reference19 articles.

1. Metabolic activation of trichloroethylene into chemically reactive metabolites toxic to the liver;Allemand;J. Pharmacol. Exp. Ther.,1978

2. Quantitative evaluation of the metabolic interaction between trichloroethylene and 1,1-dichloroethylene in vivo using gas uptake methods;Andersen;Toxicol. Appl. Pharmacol.,1987

3. Vinylidene chloride. Its metabolism by hepatic microsomal cytochrome P450 in vivo;Costa;Biochem. Pharmacol.,1982

4. Novel metabolites of trichloroethylene through dechlorination reactions in rats, mice and humans;Dekant;Biochem. Pharmacol.,1984

5. Physiologically based pharmacokinetic model for vinylidene chloride;D'Souza;Toxicol. Appl. Pharmacol.,1988

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