Polygenic risk score for problematic alcohol use predicts heavy drinking and alcohol use disorder symptoms in young adulthood after accounting for adolescent alcohol use and parental alcohol use disorder

Author:

Wang Frances L.,Hicks Brian M.,Zhou Hang,Kranzler Henry R.,Gelernter Joel,Zucker Robert A.

Funder

U.S. Department of Veterans Affairs

U.S. Public Health Service

Veterans Integrated Services Network 4 Mental Illness Research Education and Clinical Center

National Institute on Alcohol Abuse and Alcoholism

National Institute on Drug Abuse

Publisher

Elsevier BV

Subject

Pharmacology (medical),Psychiatry and Mental health,Pharmacology,Toxicology

Reference45 articles.

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2. Age-related changes in heritability of behavioral phenotypes over adolescence and young adulthood: a meta-analysis;Bergen;Twin Res. Hum. Genet.,2007

3. Comorbidity between major depression and alcohol use disorder from adolescence to adulthood;Brière;Compr. Psychiatry,2014

4. Substance use and abuse outcomes in children of alcoholics: from adolescence to young adulthood;Chassin,2002

5. Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N= 112 117);Clarke;Mol. Psychiatry,2017

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1. The genetic landscape of substance use disorders;Molecular Psychiatry;2024-05-29

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