Cadmium exposure suppresses insulin secretion through mtROS-mediated mitochondrial dysfunction and inflammatory response in pancreatic beta cells

Author:

Hong Huihui,He Haotian,Lin Xiqin,Hayuehashi Tali,Xu Jia,Zhang Jingjing,Xu Yudong,Tong Tong,Lu Yuanqiang,Zhou Zhou

Publisher

Elsevier BV

Subject

Inorganic Chemistry,Molecular Medicine,Biochemistry

Reference30 articles.

1. Uncoupling protein-2 attenuates glucose-stimulated insulin secretion in ins-1e insulinoma cells by lowering mitochondrial reactive oxygen species;Affourtit;Free Radic. Biol. Med.,2011

2. Emerging links between cadmium exposure and insulin resistance: human, animal, and cell study data;Buha;Toxics,2020

3. Cadmium induces apoptosis in pancreatic beta-cells through a mitochondria-dependent pathway: the role of oxidative stress-mediated c-jun n-terminal kinase activation;Chang;PLoS One,2013

4. Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes;Donath;J. Mol. Med.,2003

5. Pancreatic beta-cells in type 1 and type 2 diabetes mellitus: different pathways to failure;Eizirik;Nat. Rev. Endocrinol.,2020

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