Opiorphin highly improves the specific binding and affinity of MERF and MEGY to rat brain opioid receptors

Author:

Tóth Fanni,Tóth Géza,Benyhe Sándor,Rougeot Catherine,Wollemann Mária

Funder

Hungarian Research Foundation (OTKA)

Publisher

Elsevier BV

Subject

Cellular and Molecular Neuroscience,Clinical Biochemistry,Endocrinology,Physiology,Biochemistry

Reference20 articles.

1. Effects of three peptidase inhibitors, amastatin, captopril and phosphoramidon, on the hydrolysis of [Met5]-enkephalin-Arg6-Phe7] and other opioid peptides;Hiranuma;Naunyn Schmiedebergs Arch Pharmacol,1998

2. Protection against dynorphin-(1–8) hydrolysis in membrane preparations by the combination of amastatin, captopril and phosphoramidon;Hiranuma;J Pharmacol Exp Ther,2006

3. Peptidases prevent mu-opioid receptor internalization in dorsal horn neurons by endogenously released opioids;Song;J Neurosci,2003

4. Human opiorphin, a natural antinociceptive modulator of opioid-dependent pathways;Wisner;Proc Natl Acad Sci U S A,2006

5. Opiorphin peptide derivatives as potent inhibitors of enkephalin-degrading ectopeptidases;Rougeot,2009

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