A Sensitive In Vitro Approach to Assess the Hybridization-Dependent Toxic Potential of High Affinity Gapmer Oligonucleotides-Reference-Cited by-同舟云学术

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A Sensitive In Vitro Approach to Assess the Hybridization-Dependent Toxic Potential of High Affinity Gapmer Oligonucleotides

Published:2018-03 Issue: Volume:10 Page:45-54
ISSN:2162-2531
Container-title:Molecular Therapy - Nucleic Acids
language:en
Short-container-title:Molecular Therapy - Nucleic Acids

Author:

Dieckmann Andreas,Hagedorn Peter H.,Burki Yvonne,Brügmann Christine,Berrera Marco,Ebeling Martin,Singer Thomas,Schuler Franz

Publisher

Elsevier BV

Subject

Drug Discovery,Molecular Medicine

Reference28 articles.

1. The chemical evolution of oligonucleotide therapies of clinical utility;Khvorova;Nat. Biotechnol.,2017

2. Safety of antisense oligonucleotide and siRNA-based therapeutics;Chi;Drug Discov. Today,2017

3. Antisense oligonucleotide therapies: the promise and the challenges from a toxicologic pathologist’s perspective;Frazier;Toxicol. Pathol.,2015

4. Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals;Swayze;Nucleic Acids Res.,2007

5. Comparison of hepatic transcription profiles of locked ribonucleic acid antisense oligonucleotides: evidence of distinct pathways contributing to non-target mediated toxicity in mice;Kakiuchi-Kiyota;Toxicol. Sci.,2014

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