Engineering RsDddA as mitochondrial base editor with wide target compatibility and enhanced activity

Author:

Cheng Kai,Li Cao,Jin Jiachuan,Qian Xuezhen,Guo Jiayin,Shen Limini,Dai YiChen,Zhang Xue,Li Zhanwei,Guan Yichun,Zhou Fei,Tang Jin,Zhang Jun,Shen Bin,Lou XinORCID

Publisher

Elsevier BV

Subject

Drug Discovery,Molecular Medicine

Reference25 articles.

1. Mitochondrial diseases;Gorman;Nat. Rev. Dis. Prim.,2016

2. Prevalence of nuclear and mitochondrial DNA mutations related to adult mitochondrial disease;Gorman;Ann. Neurol.,2015

3. Mitochondrial disease: genetics and management;Ng;J. Neurol.,2016

4. The potential of mitochondrial genome engineering;Silva-Pinheiro;Nat. Rev. Genet.,2022

5. MitoTALEN reduces mutant mtDNA load and restores tRNA(Ala) levels in a mouse model of heteroplasmic mtDNA mutation;Bacman;Nat. Med.,2018

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