T-cell receptor gene-modified cells: past promises, present methodologies and future challenges

Author:

Tendeiro Rego Rita,Morris Emma C.,Lowdell Mark W.

Funder

Medical Research Council

National Institute for Health Research

Publisher

Elsevier BV

Subject

Cancer Research,Transplantation,Cell Biology,Genetics (clinical),Oncology,Immunology,Immunology and Allergy

Reference130 articles.

1. Chimeric Antigen Receptor- and TCR-Modified T Cells Enter Main Street and Wall Street;Barrett;J Immunol,2015

2. Optimizing T-cell receptor gene therapy for hematologic malignancies;Morris;Blood,2016

3. Novartis. Novartis receives first ever FDA approval for a CAR-T cell therapy, KymriahTM (tisagenlecleucel, CTL019), for children and young adults with B-cell ALL that is refractory or has relapsed at least twice [press release].

4. Gilead. Kite's Yescarta™ (Axicabtagene Ciloleucel) becomes first CAR T therapy approved by the FDA for the treatment of adult patients with relapsed or refractory large B-cell lymphoma after two or more lines of systemic therapy [press release].

5. Deconstructing the Form and Function of the TCR/CD3 Complex;Kuhns;Immunity,2006

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